Transfem

Orally I typically see people take 100mg to 200mg. I've also seen 300mg, but that's less common. Advice on transdermal prog is purely a DIY thing and what I've heard about dosing there is 6mg-12mg.

Mostly people take these doses once everyday, usually right before they go to bed. Some people "cycle" progesterone which means they have breaks. Some people might do two weeks of prog and then then two weeks of no prog, and I've heard cis women who take five days of prog and then two days of no prog.

Prog does not have any fancy guidelines for us to follow so a lot of the advice around it is anecdotal.

Edit: Oh yeah I should mention I do transdermal prog, 12 mg once a day before going to bed. With transdermal be sure to apply to the breasts, unlike with estradiol which should never be applied to the breasts.

Edit edit: Also, it's generally recommended to take it rectally rather than orally. Most oral prog pills can be taken rectally.

https://www.bumc.bu.edu/endo/clinics/transgender-medicine/guidelines/

Let this or an equivalent be the base against which you judge random internet stranger's recommendations.

Dunno, I made My own progesterone in My adrenal gland and went by vibes. It was a big success, so I recommend doing the same to any transfemmes who don't have access to lab grade options.

I assume you're seeing the effects you want from estradiol? Otherwise I'd suggest adjusting that first.

I've been using bioidentical micronized progesterone for a while now, and it has improved my sleep, mood and libido. I'm currently on 200mg oral, but I've also been on 100mg both oral and rectal. Didn't notice much difference in the end, so I'd recommend starting with 100mg oral and going from there if you feel it's not enough.

I never got the "drunk" feeling taking it, but if you do then rectal is probably the way to go.

100 mg, rectally, once per night - taking it orally results in the dose almost entirely being absorbed by the liver and does not sufficiently raise blood progesterone levels, so rectal administration ensures you actually are getting the dose. Unfortunately it's the only realistic alternative route of administration to oral, currently.

Also, you want to take micronized bioidentical progesterone (the ones that are in oil and come in gel capsules intended to be taken orally, they are safe to insert rectally). You don't want to take medroxyprogesterone acetate (MPA) which is often called "progesterone" and which some trans women have taken (esp. historically). MPA has some negative long-term health risks associated with it..