this post was submitted on 10 Mar 2026
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I unfortunately live in a not very trans friendly state in the US (more like trans hostile tbh) so I've been doing my HRT pretty much solo/without seeing doctors. Been doing mono estradiol enanthate for about a year now following the manufacturer's recommendations (0.15 mL every 7 days) and wanted to try getting on prog but i'm not sure what dosage i should be at. any recommendations?

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[–] leftascenter@jlai.lu 0 points 7 months ago (3 children)

https://www.bumc.bu.edu/endo/clinics/transgender-medicine/guidelines/

Let this or an equivalent be the base against which you judge random internet stranger's recommendations.

[–] Kayday@lemmy.world 0 points 7 months ago

Unfortunately this says nothing about progesterone.

[–] dandelion@lemmy.blahaj.zone 0 points 7 months ago* (last edited 7 months ago) (1 children)

Estradiol valerate 5–20mg i.m./2 weeks or cypionate 2–10mg i.m./week

injecting estradiol valerate once every 2 weeks is pretty wild, tbh - it has a relatively short half-life when injected and has a spikey metabolism

it also suggests injecting cypionate more frequently (once a week) despite a longer half-life‼️

I find this very suspicious and unlikely to result in the best outcomes.

EDIT: the recommendations are very old, from 2013

EDIT2: these guidelines were found to be problematic and revised in 2024 to update estradiol valerate doses to lower and more frequent doses of ~5 mg / week, this is much more reasonable and aligns with what I found reasonable (I myself inject 4 mg once a week.)

https://journals.sagepub.com/doi/10.1089/trgh.2023.0209

one of the co-authors of the revised guideline was Joshua Safer, who was one of the co-authors of the original 2013 guidelines fwiw

It might be good to find more up to date guidelines, I wouldn't take these 2013 guidelines too seriously.

[–] applebusch@lemmy.blahaj.zone 0 points 7 months ago

Just wanted to say I do 5mg estradiol valerate once a week intramuscular and 100mg progesterone rectally every day. I found this had all the expected effects before getting my levels checked, and getting my levels checked showed I had estrogen levels on the high end of the expected range and my testosterone was sufficiently suppressed even being a little below the normal cis woman range. I'm really happy with my results so far and was pleasantly surprised that this dosage is what I was prescribed from the beginning. I went to planned parenthood, and while some of their recommendations are a little dated (they said subcutaneous injections and taking progesterone rectally weren't recommended) I'm happy they at least had reasonable doses and didn't make me jump through hoops to get it. If anything I think I might want to go up in dosage on the progesterone because I haven't really had the increased libido people talk about.

[–] LadyAutumn@lemmy.blahaj.zone 0 points 7 months ago

Ironically doesn't mention progesterone.