this post was submitted on 16 Apr 2026
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[–] AndyMFK@lemmy.dbzer0.com 7 points 1 week ago (2 children)

They never worked. For some unlucky people, anti-depressants just straight up don't work. If you're new at it, keep at it, but if it's been a few months it might be time to switch medication. if you've already switched a bunch of times, they might not work for you and your only option is probably therapy

[–] Zak@lemmy.world 3 points 1 week ago (1 children)

"Some unlucky people" turns out to be 85% of people with depression. What that suggests to me is that depression is a syndrome with multiple causes, and typical antidepressant drugs treat one of them.

[–] DeathByBigSad@sh.itjust.works 1 points 1 week ago* (last edited 1 week ago) (1 children)

Seems to only mention SSRI specifically, not about antidepressants in general

Also this: "suggested that the active ingredients in 10 of the most popularly prescribed antidepressant medications made a meaningful difference in only 15 percent of the patients who took them, almost always in those patients suffering from the most severe depression"

So yeah... that's me lmfao...

[–] massive_bereavement@fedia.io 3 points 1 week ago

Hey OP, I'm glad you're fighting this fight. You're worth it and I'm glad to have you around.

[–] neaptide@lemmy.world 1 points 1 week ago* (last edited 1 week ago)

There actually are other options for treatment-resistant depression, which is defined as depression that has little or no response to standard treatments like antidepressants.

  • Transcranial magnetic stimulation (TMS): uses magnetic currents to stimulate the brain while awake, typically provided 5x per week for 6 weeks (although there are now newer protocols that are much shorter in duration)
  • Ketamine: a general anesthetic drug typically provided via a nose spray 1-2 times per week for 8 weeks
  • Electroconvulsive therapy (ECT): uses electricity to induce a small seizure in the brain under sedation, typically provided 2-3 times per week for 3-4 weeks

Source: https://www.mayoclinic.org/diseases-conditions/depression/in-depth/treatment-resistant-depression/art-20044324

I try to spread the word about these treatments when I can because TMS helped me immensely after trying just about every antidepressant out there with no luck.