Drugs

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Welcome to Drugs, now under new management!

This community is for the discussion of any drugs and any topics pertaining to drugs (except sourcing).

Specific substances / classes of substances may have their own dedicated communities. See "Communities" section below.

Please contact @7101334@lemmy.world if you're interested in volunteering as a moderator!

`Communities`

c/weed - Cannabis Discussion
c/psy - Psychedelic Discussion
c/drank - Alcohol Discussion
c/opi - Opiate Discussion

`Rules`

No Sourcing - Do not request sources of any drugs at any time. This includes unregulated research chemicals. Any attempts, including "hit me up in DMs" type of requests, will result in a ban. This rule is necessary to keep this community open.

Harm Reduction - Do not recommend inherently dangerous doses or combinations of substances, or otherwise encourage behavior more risky than drug use already is by default. Clear attempts at causing intentional harm will result in a ban.

Avoid Dangerous Recommendations - Avoid recommending substances that have a reasonable chance of causing considerable harm to the user. For example, DPH, inhalants, or opioids. This rule is necessary to conform with Lemmy.World's Terms of Service. Posts violating this rule will be removed.

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`Credit`

Concept from 420chan.org. Thanks for the years of fun, Kirt & others. (If you're unfamiliar, don't worry, it was nothing like 4chan.)
Icon image from 420chan.org.

founded 3 years ago

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New study reinforces likelihood that "kykeon", the sacred elixir of the Eleusinian Mysteries, was composed of LSA and related compounds (www.nature.com)

submitted 3 months ago by 7101334@lemmy.world to c/drugs@lemmy.world

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Abstract

This study revisits the hypothesis that Claviceps purpurea (Fr.) Tul., a fungus infecting cereals and producing ergot alkaloids (EAs), was the psychedelic agent in kykeon, the sacred elixir of the Eleusinian Mysteries. Although archaeological evidence supports this link, experimental data confirming the transformation of toxic ergopeptides into psychoactive lysergic acid amide derivatives in putative ancient preparations remain limited. The potential hydrolysis products of ergot were investigated using a technique that could have been readily applied by the priestesses of Eleusis, notably reacting in lye. Pulverized sclerotia were refluxed in solutions of lye and in distilled water. Samples obtained after liquid-liquid extractions were analyzed with 1H-NMR and UHPLC/Q-TOF-HRMS. The 1H NMR spectra demonstrated conversion of toxic ergopeptides, present in control samples but absent at all reaction times in 5% w/v ergot treated with pH 12.5 lye, where characteristic peaks for lysergic acid amide (LSA; ergine) and isolysergic acid amide (iso-LSA; isoergine; erginine) appeared. UHPLC/Q-TOF-HRMS quantitation confirmed this conversion, yielding 0.54 mg LSA and 0.48 mg iso-LSA per gram of ergot at 120 min. The chemical transformation of toxic EAs to psychoactive compounds, utilizing ancient technology, was demonstrated and supports the “psychedelic Eleusis” hypothesis.

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