this post was submitted on 14 Mar 2025
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Have we accidentally bred some dogs for obesity? (arstechnica.com)
submitted 1 year ago by bestboyfriendintheworld@sh.itjust.works to c/science@mander.xyz
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[–] jet@hackertalks.com 0 points 1 year ago* (last edited 1 year ago) (1 children)

Let me introduce you to the The Carbohydrate-Insulin Model of Obesity - Beyond “Calories In, Calories Out”: https://doi.org/10.1001/jamainternmed.2018.2933 - Full Paper Here

TLDR: Insulin is the cause of almost all obesity you see. Carbohydrates drive blood sugar, blood sugar drives insulin, insulin drives weight gain. As a good example - T1Ds who don't take their insulin wont gain weight, no matter how much they eat.

[–] Tecovirimat@lemmy.dbzer0.com 0 points 1 year ago (1 children)

T1D who don’t take their insulin won’t gain weight because of vomiting and dying from diabetic ketoacidosis. Sorry, but is is a horrible example and whoever has DM type 1, please take your insulin. People are really dying from DKA and while it is hard to prevent some factors triggering DKA, compliance with insulin is definitely within our control.

Insulin (and to be more precise it’s baseline level and spikes) is one of the obesitygenic factors. But there are much more other factors there too, and reducing such complex multifactorial disease as obesity to insulin only is incorrect.

Otherwise good paper and thank you for adding full article!

[–] jet@hackertalks.com 0 points 1 year ago (1 children)

Insulin (and to be more precise it’s baseline level and spikes) is one of the obesitygenic factors. But there are much more other factors there too, and reducing such complex multifactorial disease as obesity to insulin only is incorrect.

I'd love to learn about the other factors. Can you illuminate a more correct understanding for me?

[–] Tecovirimat@lemmy.dbzer0.com 0 points 1 year ago

Pathophysiology and risk factors are actually a pretty much half of the curriculum for a separate medical specialty. Here are some resources for a different depth levels of this rabbit hole:

Basic level: https://www.cdc.gov/obesity/risk-factors/risk-factors.html

Moderate to deep:

Too deep (mostly for medical professionals) and more expensive: Course of lectures at Columbia university: https://www.ihn.cuimc.columbia.edu/education/continuing-medical-education-cme/columbia-cornell-obesity-medicine