nootropics & friends

Scientists at the University of Queensland partnered with researchers from the University of Minnesota to examine levels of adenosine triphosphate (ATP) - known as the "energy currency" molecule - in the brains and blood cells of young people with depression.

cross-posted from: https://piefed.social/c/science/p/1708790/alzheimer-s-fully-reversed-in-mice-scientists-say

In our latest attempts to make lab rats immortal, a new compound has been shown to reverse late stage Alzheimer's disease in lab mice. This is a rare case where the title isn't even clickbait.

cross-posted from: https://lemmy.today/post/44911953

In mice (of course) and human tissue exvivo. Earlier phase 1 studies with 15-PGDH has shown that it is safe and active in healthy volunteers.

Reference: “Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration” by Mamta Singla, Yu Xin Wang, Elena Monti, Yudhishtar Bedi, Pranay Agarwal, Shiqi Su, Sara Ancel, Maiko Hermsmeier, Nitya Devisetti, Akshay Pandey, Mohsen Afshar Bakooshli, Adelaida R. Palla, Stuart Goodman, Helen M Blau and Nidhi Bhutani, 27 November 2025, Science. DOI: 10.1126/science.adx6649

Researchers have synthesized enhanced vitamin K analogues that outperform natural vitamin K in promoting neuron growth. The new compounds, which combine vitamin K with retinoic acid, activate the mGluR1 receptor to drive neurogenesis. They also efficiently cross the blood-brain barrier and show stability in vivo.

Archive article: https://archive.ph/fWqbL

TLDR: Middle-aged rats who were given varying doses of β-hydroxy β-methylbutyrate (HMB), a metabolite of the essential amino acid leucine showed improvements in memory.

However the doses are ridiculously high IMO: 225 (low), 450 (medium), and 900 (high) mg/kg body weight/day.

cross-posted from: https://lemmy.world/post/32461703

cross-posted from: https://rss.ponder.cat/post/221468

From Scientific American via this RSS feed

cross-posted from: https://metawire.eu/post/105642

A study found that people who had suffered the herpes virus had an 80% increased risk of Alzheimer’s disease.

Our findings revealed AlCl3 exposure induced significant neurobehavioral deficits, oxidative stress, neuroinflammation, and loss of the Purkinje cell layer of the cerebellum. Treatment with apigenin attenuated neuroinflammation and enhanced learning and memory with significant improvement in recognition index.

Scripps Research scientists created a stable form of carnosic acid, observing greater memory function and other disease improvements in mice.

Researchers at the University of Reading tested participants who ate a walnut-enriched breakfast and found significant cognitive benefits compared to a nut-free meal. The study highlights the potential of walnuts as a natural brain enhancer, but more research is needed to fully understand their impact.

Seven days after their splurge had ended, the junk-food group had lower brain activity in two regions associated with memory and response to visual food cues.

Now, a new study that will be presented at the American Academy of Neurology’s 77th Annual Meeting in early April 2025 provides further evidence of a link between more exercise with less risk of developing certain neuropsychiatric diseases.

New research suggests that certain antidepressants can accelerate cognitive decline in people with dementia. At the same time, some drugs appear to be less harmful than others, which can help doctors make better treatment decisions, according to the study.

A new study suggests that omega-3 and vitamin D supplements, when combined with regular exercise, may help slow biological aging by several months over a 3-year period.

Researchers analysed data from the DO-HEALTH trial, which tracked over 700 older adults and found that those who followed this regimen experienced measurable benefits at the molecular level.

The researchers said that even though the effects might seem small, they could still make a big difference for public health — helping to lower the risk of age-related health issues and improving the well-being of older adults.

• The primary finding of this analysis is that resistance training significantly improved brain-derived neurotrophic factor (BDNF) among older adults aged 60 years or more. • The effects of resistance training on BDNF levels were significant regardless of intervention duration or gender. However, the effects were more pronounced in older adults with poor health. • Resistance training caused improvements in depressive symptoms in older adults.

Saw this new supplement carried by Cosmic. Big fan of bromantane so was curious when I saw this being compared to it. The reviews of all though seem to imply that it’s being used for workouts when I’m more interested in the anxiolytic affect, fatigue reduction, and focus.